Tadalafil is one of the most popular drugs that many men use to treat erectile dysfunction (ED) issues. The term describes the active ingredient and not the drug itself. The most popular trade name of Tadalafil is Cialis. There are a number of its generics which, although being not that popular compared to Cialis, nevertheless, have the same active ingredient, Tadalafil.
Generics usually have absolutely identical effect as the original drug but cost noticeably less. Some of the Tadalafil generics are Tadalista , Tadaga, Modula, Tadacip, Blazer, Tadora and some others. Most of them have the standard dosage of 20 mg of Tadalafil in each pill. For those who find it a bit excessive, there are also dosages of 10, 5, and even 2.5 mg.
The company credited with the discovery of Tadalafil is Glaxo Wellcome, which is now known as GlaxoSmithKline, in co-operation with ICOS, a biotechnology company based in Bothell, Washington. It was a time when Pfizer discovered the benefits of Sildenafil and its usage against ED problems. The substance Glaxo Wellcome was studying was a compound that had been given the code name IC351. The researchers discovered that this also caused men to achieve an erection. After extensive tests and trials that lasted a few years, the Food and Drug Administration of the United States of America finally approved Tadalafil (under the name Cialis) for sale in the US on November 21 of 2003.
The way that Tadalafil works is the same as Sildenafil. This should come as no surprise since they both belong to the same group, called PDE5 inhibitors.
These inhibitors block the action of the PDE5 enzyme, one that prevents the increase of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum, a small area in the man’s genitals. Once the PDE5 is unable to function properly, an increase of the cGMP levels leads to the achievement of an erection that is sufficient for a normal sexual intercourse. Men who do not suffer from erectile dysfunction have their bodies produce nitric oxide after a certain degree of sexual stimulation. This oxide “pairs” with guanylase cyclase and increases the concentration of cGMP.
Even though the mechanism of action of Tadalafil is the same and their side effects are also almost identical, each one of these substances may have different results from one man to another. So, there is no real answer to the question “which one is better?“ since the most important factor is the body of the user and how well it interacts with each one of the drugs.
There is not a single reason for any man to be embarrassed to discuss or treat an ED problem. The best thing you can do if you suffer from it is consult a doctor, use the drug of your choice, and enjoy a normal and pleasant sexual intercourse.