The word “Sildenafil” is unknown to the overwhelming majority of men, even the ones who use it. This does not derive from the fact that the users of the drug are not adequately informed about the drugs they are using. The reason is that this is the name of the chemical contained in the pills of the drug known as Viagra.
Sildenafil is a synthetic substance that was initially created by the company Pfizer in their research lab located in the city of Sandwich, England. Its original purpose was way different than what it was finally used for. Scientists wanted to invent a new drug to treat symptoms of ischemic heart disease (IHD) and also hypertension (the constantly increased level of blood pressure). Unfortunately for the research of that time, Sildenafil had no effect on IHD but the researches noticed that it caused erections to men that took it. It did not take long for the drug to be patented (1996) to treat erectile dysfunction issues. It was approved by the FDA two years later, in March of 1998.
There are many drugs that contain Sildenafil, the most famous of which is Viagra. They all have the same mechanism of action and the same side effects, so analyzing them separately is pointless. Some of the drugs containing Sildenafil are: Caverta, Penegra, Eriacta.
The mechanism of action is not that complicated. Under normal circumstances, the male body produces nitric oxide after receiving sufficient sexual stimulation. This nitric oxide is released in the corpus cavernosum and “bonds” with guanylate cyclase, a different chemical substance that in turn increases the levels of cyclic guanosine monophosphate (cGMP). In the body of a man that has erectile dysfunction issues the concentration levels of cGMP cannot be increased due to the presence and actions of phosphodiesterase type 5 (PDE5), an enzyme that prevents the aforementioned increase. This is where Sildenafil steps in, blocking the effect of PDE5 and allowing the cGMP quantity to increase sufficiently in order to achieve and maintain an erection. This is why Sildenafil is known as PDE-5 inhibitor.
Erectile dysfunction problems affect the lives of thousands of men of different ages but thanks to medical science and its constant breakthroughs, these men are able to battle the condition with more than one way. It is always great to have more than one option since every single drug has a different degree of effectiveness from one person to another.